David C Rubinsztein Selected Research

Disaccharides

2/2016

Mystery solved: Trehalose kickstarts autophagy by blocking glucose transport.

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David C Rubinsztein Research Topics

Disease

67	Huntington Disease (Huntington's Disease) 12/2023 - 05/2002
63	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2023 - 05/2002
23	Parkinson Disease (Parkinson's Disease) 12/2023 - 05/2002
21	Alzheimer Disease (Alzheimer's Disease) 10/2021 - 05/2002
15	Starvation 12/2021 - 04/2010
9	Tauopathies 06/2023 - 01/2006
9	Oculopharyngeal Muscular Dystrophy 03/2011 - 04/2002
8	Spinocerebellar Ataxias (Spinocerebellar Ataxia) 01/2022 - 01/2006
7	Proteostasis Deficiencies 01/2018 - 11/2004
5	Neoplasms (Cancer) 12/2020 - 07/2011
4	Infections 03/2024 - 09/2011
4	Dementia (Dementias) 12/2023 - 02/2006
4	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 12/2023 - 09/2008
4	Machado-Joseph Disease (Spinocerebellar Ataxia Type 3) 01/2017 - 10/2006
3	Inflammation (Inflammations) 01/2023 - 10/2015
3	Disease Progression 01/2020 - 04/2003
2	Carcinogenesis 01/2022 - 04/2015
2	Mitochondrial Diseases (Mitochondrial Disease) 12/2015 - 06/2015
2	Frontotemporal Dementia (Semantic Dementia) 03/2014 - 01/2006
2	Muscle Weakness 06/2010 - 01/2006
2	Communicable Diseases (Infectious Diseases) 11/2007 - 06/2007
1	Reperfusion Injury 03/2024
1	Virus Diseases (Viral Diseases) 03/2024
1	Progeria (Hutchinson Gilford Syndrome) 01/2024
1	Synucleinopathies 12/2022
1	Multiple System Atrophy 12/2022
1	Oculocerebrorenal Syndrome (Lowe Syndrome) 01/2021
1	Congenital Structural Myopathies (Centronuclear Myopathy) 01/2020
1	Hypoxia (Hypoxemia) 01/2018
1	Movement Disorders (Movement Disorder) 12/2017
1	Ataxia (Dyssynergia) 09/2017
1	Non-alcoholic Fatty Liver Disease 02/2016
1	Neuroblastoma 12/2015

Drug/Important Bio-Agent (IBA)

79	Proteins (Proteins, Gene)FDA Link 03/2024 - 05/2002
38	polyglutamineIBA 10/2020 - 05/2002
9	Mutant Proteins (Protein, Mutant)IBA 01/2020 - 04/2003
7	SynucleinsIBA 12/2022 - 04/2006
7	Sirolimus (Rapamycin)FDA Link 02/2010 - 06/2004
6	Glucose (Dextrose)FDA LinkGeneric 12/2021 - 02/2006
6	Protein AggregatesIBA 10/2021 - 05/2002
6	Huntingtin ProteinIBA 10/2020 - 05/2003
6	polyalanineIBA 03/2011 - 01/2006
5	alpha-SynucleinIBA 08/2010 - 01/2006
4	Ataxin-3IBA 01/2017 - 10/2006
4	Poly(A)-Binding Protein IIIBA 03/2011 - 04/2002
4	LithiumIBA 01/2008 - 09/2002
3	Mechanistic Target of Rapamycin Complex 1IBA 01/2024 - 04/2011
3	Phosphotransferases (Kinase)IBA 12/2021 - 01/2019
3	LipidsIBA 12/2021 - 01/2019
3	Amyloid (Amyloid Fibrils)IBA 10/2021 - 10/2017
3	Amyloid beta-PeptidesIBA 10/2020 - 02/2005
3	TrehaloseIBA 02/2016 - 01/2006
2	ChemokinesIBA 06/2023 - 01/2023
2	ProteomeIBA 01/2023 - 11/2007
2	InterferonsIBA 01/2020 - 10/2015
2	Carrier Proteins (Binding Protein)IBA 01/2019 - 06/2010
2	Rilmenidine (Hyperium)IBA 12/2017 - 06/2010
2	Beclin-1IBA 01/2017 - 08/2012
2	BuffersIBA 08/2015 - 04/2010
2	AntioxidantsIBA 11/2012 - 09/2010
2	Apolipoproteins E (ApoE)IBA 09/2010 - 09/2006
2	temsirolimus FDA Link 01/2010 - 06/2004
2	UbiquitinIBA 01/2010 - 11/2007
2	TOR Serine-Threonine KinasesIBA 01/2010 - 06/2007
2	Dyneins (Dynein)IBA 10/2005 - 07/2005
2	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA 01/2005 - 03/2004
2	Cholinergic Agents (Cholinergics)IBA 01/2005 - 03/2004
1	linoleamideIBA 03/2024
1	sapropterin (tetrahydrobiopterin)FDA Link 03/2024
1	7,8-dihydrobiopterinIBA 03/2024
1	Chloroquine (Aralen)FDA LinkGeneric 03/2024
1	Thiobarbituric Acid Reactive SubstancesIBA 03/2024
1	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 03/2024
1	Malondialdehyde (Propanedial)IBA 03/2024
1	Green Fluorescent ProteinsIBA 03/2024
1	Glutathione (Reduced Glutathione)IBA 03/2024
1	Reactive Oxygen Species (Oxygen Radicals)IBA 03/2024
1	Alkynes (Acetylenes)IBA 03/2024
1	LigandsIBA 06/2023
1	Tamoxifen FDA LinkGeneric 01/2023
1	NF-kappa B (NF-kB)IBA 01/2022
1	CateninsIBA 01/2022
1	Phospholipids (Phosphatides)FDA LinkGeneric 12/2021
1	phosphatidylinositol 3,5-diphosphateIBA 12/2021
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 01/2021
1	p300-CBP-associated factorIBA 01/2021
1	Adenosine Triphosphatases (ATPase)IBA 01/2021
1	Mechanistic Target of Rapamycin Complex 2IBA 12/2020
1	Dynamin IIIBA 01/2020
1	Amino Acids FDA Link 01/2020
1	tau Proteins (tau Protein)IBA 01/2020
1	Phosphodiesterase 5 InhibitorsIBA 01/2020
1	Antihypertensive Agents (Antihypertensives)IBA 01/2019
1	Felodipine (Agon)FDA LinkGeneric 01/2019
1	L-Type Calcium Channels (Dihydropyridine Receptor)IBA 01/2019
1	DisaccharidesIBA 02/2016
1	Adenosine Monophosphate (AMP)IBA 02/2016
1	Protein Kinases (Protein Kinase)IBA 02/2016

Therapy/Procedure

13	Therapeutics 03/2024 - 01/2006
3	Drug Therapy (Chemotherapy) 05/2015 - 11/2004